Authors (including presenting author) :
Tsang FHR(1), Chan EWY(2), Wong YF(1)
Affiliation :
(1)Pharmacy Department, United Christian Hospital; (2)Department of Pharmacology and Pharmacy, The University of Hong Kong
Introduction :
Recent evidence suggested that paracetamol may be a viable medical agent for the closure of haemodynamically significant Patent Ductus Arteriosus (PDA) in preterm neonates.
Objectives :
This study aims to evaluate the local experience on the efficacy of IV paracetamol compared to IV ibuprofen in the closure of hsPDA in preterm neonates, and to compare the safety profile of paracetamol to that of ibuprofen.
Methodology :
This retrospective study was conducted in United Christian Hospital where preterm neonates being medically treated for PDA in the NICU throughout a 52-month period from September 2013 to December 2017 were enrolled. The primary outcome was to compare the closure rates between two treatments. The secondary outcome was to explore other PDA closure related parameters and safety profiles of the two drugs. Baseline differences were observed in PDA sizes and frequency of antibiotic use, therefore analysis of such parameters were excluded.
Result & Outcome :
Forty-nine enrolled patients were grouped according to treatment received to ibuprofen group (n = 24) and paracetamol group (n = 25). PDA was closed in 12 (50%) of the patients in ibuprofen group and 12 (48%) in the paracetamol group. A significantly higher incidence of retinopathy of prematurity (ROP) (p = 0.0465) was found in the ibuprofen group, and a significantly higher peak bilirubin level (p = 0.0199) were found in the paracetamol group. No statistically significant differences were found with other safety parameters.
Co-location with:
